pede4dPhosphodiesterase 4D (PDE4D) expression is upregulated in angiotensin (Ang) II-induced hypertensive mice. We first established a hypertensive model in wild-type (WT,The goal of this study was to determine whether a phosphodiesterase-4D (PDE4D) allosteric inhibitor (BPN14770) would improve cognitive function and behavioral outes in patients with fragile X